Growth Problems

Growth Problems – Endocrine
– Mid-parental height:
In a boy: [(Father’s height + (Mother’s height + 14)) divided by 2] ± 10 cm
In a girl: [(Father’s height – 14) + Mother’s height) divided by 2] ± 8.5 cm
– Most common causes of short stature:
infancy: nutrition problems
childhood: growth hormone problems
teenage years: puberty problems
– Growth failure: height velocity below the 25th centile (<10th centile is almost certainly pathological)
– Battery of tests for children with severe short stature and reduced growth velocity:
Bone age, growth velocity
Bloods: ESR, CRP, FBC, U+E, LFT, coeliac screen, TFT, insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), karyotype, FSH/LH